Die Mehrzahl der Träger einer beta-Thalassämie (Thalassämia minor) hat keine gesundheitlichen Probleme. Interessanterweise haben insbesondere Männer, die Träger sind, sogar ein relativ geringes Risiko, im Verlauf einen Bluthochdruck zu entwickeln oder einen Herzinfarkt oder Schlaganfall zu erleiden. Nur etwa jeder fünfte Patient mit einer Thalassaemia minor klagt über Beschwerden einer leichten Blutarmut wie zum Beispiel rasche Erschöpfbarkeit und Müdigkeit. Eine Behandlung ist. Beta thalassemias are a group of inherited blood disorders. They are forms of thalassemia caused by reduced or absent synthesis of the beta chains of hemoglobin that result in variable outcomes ranging from severe anemia to clinically asymptomatic individuals. Global annual incidence is estimated at one in 100,000. Beta thalassemias occur due to malfunctions in the hemoglobin subunit beta or HBB. The severity of the disease depends on the nature of the mutation. HBB blockage over. Die homozygote Form der Beta-Thalassämie wird auch als Thalassaemia major bezeichnet, die heterozygote als Thalassaemia minor. Die Minor-Form zeigt meist nur eine leichte, hypochrome mikrozytäre Anämie, wesentliche klinische Symptome werden in der Regel nicht beobachtet Thalassämie minor: der Betreffende hat ein verändertes oder fehlendes Gen (zusammen mit dem Gen einer normalen Beta-Kette). Er wird als heterozygoter Träger einer Beta-Thalassämie bezeichnet. Menschen mit einer Thalassämie minor haben eine leichtgradige Anämie mit geringer Absenkung des Hämoglobins im Blut
4.1 Beta-Thalassaemia minor Träger einer β-Thalassaemia minor sind meistens klinisch unauffällig oder gering symptomatisch. In der einzigen dazu vorliegenden systematischen Studie, die in Sri Lanka durchgeführt wurde, wiesen bis zu 20 Prozent der Betroffenen Symptome vergleichbar denen bei milder Eisenmangelanämie auf [ 10] Der verminderte Hämoglobingehalt der roten Blutkörperchen führt zu einem vermehrten Abbau derselben. Symptome einer Thalassämie sind eine Verringerung der Knochensubstanz, Größenzunahmen bei Milz und Leber sowie Wachstumsverzögerung und Deformationen. Zur Diagnose führt eine spezifische Blutuntersuchung (Blutausstrich) . Die im Überschuss vorhandenen α-Globinketten sind schlecht wasserlöslich und präzipizieren bereits in den erythroiden Vorläuferzellen im Knochenmark Die β-Thalassämie wird in zwei Formen eingeteilt, die Thalassaemia minor und die Thalassaemia major. Genetik der β-Thalassämie. Die β-Thalassämie wird durch Mutationen verursacht, die in DNA-Sequenzen liegen, die für das korrekte Splicing des primären β-Globin-Transkripts notwendig sind
Borgna-Pignatti C, Carnelli V, Caruso V et al. Thromboembolic events in beta thalassemia major: an Italian multicenter study. Acta Haematol 99:76-79, 1998. Acta Haematol 99:76-79, 1998. PMID:955445 This condition is called thalassemia minor or beta-thalassemia. Two mutated genes, your signs and symptoms will be moderate to severe. This condition is called thalassemia major, or Cooley anemia. Babies born with two defective beta hemoglobin genes usually are healthy at birth but develop signs and symptoms within the first two years of life. A milder form, called thalassemia intermedia, also can result from two mutated genes Beta thalassemia major, the homozygous state when the gene is inherited from both parents, is characterized by hemolytic anemia (i.e., early breakdown of red blood cells). Beta thalassemia major, also known as Cooley's anemia or Mediterranean anemia, is widespread throughout the Middle East, Southern Europe, Iran, and across southern India and South-East Asia. Globally, nearly 75 percent of. Krankheitsbezeichnung: -Thalassämie (ICD-10 D 56.1) 1. Definition und Basisinformation Die Einteilung der -Thalassämien erfolgt nach klinischen Gesichtspunkten in Thalassaemia minor = heterozygote -Thalassämie, Thalassaemia major = i.d.R. homozygote oder gemischt-heterozygote -Thalassämie mit Transfusionsabhängigkeit (s. Kap. 4.2.) und. Beta thalassaemia major is the most severe type. Other types include beta thalassaemia intermedia, alpha thalassaemia major and haemoglobin H disease. It's also possible to be a carrier of thalassaemia, also known as having the thalassaemia trait
Beta Thalassemia Minor. This form of thalassemia usually has mild symptoms and the patients do not require blood transfusion. Although this condition is not life-threatening but quality of life may be affected due to mild or moderate anemia. This form of the condition is also called as beta thalassemia trait. Sickel-beta thalassemia. Some individuals inherit one gene for beta thalassemia from. Thalassemia Minor. the condition in which a person inherits one defective gene from either of carrier parents is termed as thalassemia minor. This person is termed as heterozygous for beta thalassemia. He may have no symptoms or mild symptoms of anemia. This condition is very similar to mild iron deficiency anemia. However, a person with thalassemia minor has normal levels of iron. It is not a. Beta thalassemia is a blood disorder that reduces the production of hemoglobin. Hemoglobin is the iron-containing protein in red blood cells that carries oxygen to cells throughout the body. In people with beta thalassemia, low levels of hemoglobin lead to a lack of oxygen in many parts of the body Beta-thalassemia is a blood disorder that reduces the body's production of hemoglobin. Low levels of hemoglobin lead to a shortage of mature red blood cells and a lack of oxygen in the body. People with beta-thalassemia have anemia, which can cause paleness, weakness, fatigue, and more serious complications.
Bei Beta-Thalassämie major (die manchmal auch Cooley-Anämie genannt wird) treten schwere Symptome einer Anämie auf (wie Erschöpfung, Schwäche und Kurzatmigkeit), und die Betroffenen können auch Gelbsucht (verursacht Gelbfärbung der Haut und des Weißen im Auge), Hautgeschwüre und Gallensteine haben. Die Betroffenen können zudem eine vergrößerte Milz aufweisen Beta-thalassemia major will usually present clinically between the ages of 6 and 24 months. Affected infants have severe microcytic anemia, fail to thrive, become progressively pale, develop hepatosplenomegaly that may distend the abdomen, have mild jaundice, and may also have feeding problems and recurrent fevers due to hypermetabolic state or inter-current infection. Symptome bei Thalassaemia major Die Thalassaemia major verursacht bereits im ersten Lebensjahr eine schwere Blutarmut. Bei vielen Kindern und Jugendlichen mit ß-Thalassämie besteht daher bereits ab dem vierten Lebensmonat ein lebenslanger und regelmäßiger Bedarf an Bluttransfusion en Det finnes noen ganske få familier med etnisk opprinnelse i Norge med beta-thalassemia minor. Talassemi var svært sjelden i Norge inntil innvandringen fra asiatiske land skjøt i været i løpet av 1970-årene. Talassemi nedarves autosomalt recessivt. Inndeling I tillegg til om genfeilen sitter i alfa- eller betakjedene, deles talassemiene ofte inn i thalassemia major og thalassemia minor.
Beta thalassemia minor, also known as beta thalassemia trait, is a common condition. Beta thalassemia major was first described in the medical literature in 1925 by an American physician - Thomas Cooley. Beta thalassemia major is also known as Cooley's anemia Thalassemia major. Thalassemia major is the most severe form of beta thalassemia. It develops when beta globin genes are missing. The symptoms of thalassemia major generally appear before a child.
There are multiple forms of thalassaemia. Beta thalassaemia is the most common form of thalassaemia, and it is divided into thalassaemia trait (sometimes called thalassaemia minor) and thalassaemia major. Beta thalassaemia is found in people from many countries around the world, but it is more common in people of Mediterranean, Middle Eastern or Asian origin. It is rare in people of northern. Thalassämie minor kann erst im Alter von >8 Monaten sicher ausgeschlossen oder nachgewiesen werden. Die Abklärung erfolgt durch ein vollständiges Hämatogramm (Hb, MCV, MCH, Retikulozyten) und die Hb-Chromatographie (HPLC) sowie gegebenenfalls molekulare Analysen. Wird bei beiden Eltern eine b-Thalassämie minor nachgewiesen, ist eine genetische Beratung unerlässlich, da das Risiko für. 5 Therapie. Bei der Minorform der Thalassämie minor ist keine Therapie notwendig. Bei der Intermedia-Form besteht inkonstanter Transfusionsbedarf. Die Major-Form erfordert die Hb-abhängige Gabe von Erythrozytenkonzentraten etwa alle 3 Wochen sowie eine Eiseneliminationstherapie ab dem 3
Beta-thalassemia minor (BTM) is a common genetic blood disorder in Turkey. BTM is a single-gene disease that causes a decrease in beta globin production. We describe a girl aged 4 years and 4 months referred to our department due to speech delay, inability to establish social communication and overactivity. She was diagnosed with ASD according to DSM-5 criteria and Beta-thalassemia minor. Beta thalassemia minor. Available tests. 9 tests are in the database for this condition. Check Related conditions for additional relevant tests. Clinical tests (9 available) Molecular Genetics Tests. Linkage analysis (1) Sequence analysis of the entire coding region (9) Deletion/duplication analysis (3) Targeted variant analysis (1) Related conditions Help. Explore related conditions in. thalassemia carrier, beta-thalassemia trait or heterozygous beta-thalassemia. Apart from the rare dominant forms, subjects with thalassemia major are homozygotes or compound heterozygotes for beta0 or beta+ genes, subjects with thalassemia intermedia are mostly homozygotes or compound heterozygotes and subjects with thalassemia minor are mostly heterozygotes. Thalassemias can cause significan Beta thalassemia syndromes are a group of hereditary disorders characterized by a genetic deficiency in the synthesis of beta-globin chains. In the homozygous state, beta thalassemia (ie.
Thalassemia minor: If the newly born baby inherits single mutated gene, then it is termed as thalassemia minor and the symptoms seen are few to moderate. The child is said to be heterozygous for β-thalassemia. No any transfusions or occasional transfusions is required. It is further divided as: i) thalassemia minima: shows no or few symptoms Beta-Thalassämie. Bei einer Thalassämie kommt es zur Störung der Bildung des roten Blutfarbstoffes (Hämoglobin). Grund dafür sind angeborene Veränderungen (Mutationen) der Erbsubstanz. Bei dieser Gruppe an Erkrankungen werden bestimmte Globinketten (Eiweißketten) in zu geringem Ausmaß oder gar nicht gebildet. Diese sind Bausteine des roten Blutfarbstoffs Hämoglobin, und dieses.
I made this video to bring about awareness of this blood disorder that I have and I know there are others out there, like me, who struggle to find informatio.. Beta-thalassemia major will usually present clinically between the ages of 6 and 24 months. Affected infants have severe microcytic anemia, fail to thrive, become progressively pale, develop hepatosplenomegaly that may distend the abdomen, have mild jaundice, and may also have feeding problems and recurrent fevers due to hypermetabolic state or inter-current infection. Beta-thalassemia minor (beta-thalassemia trait or beta-thalassemia carrier) Heterozygous betaN/beta 0 or beta N /beta + Usually clinically asymptomatic, but some patients may have mild microcytic anemia: Heterozygous beta N /beta ++ (silent carriers) Silent carriers have no hematological abnormalities: Beta-thalassemia intermedia: Homozygous beta + /beta Beta thalassemia major causes severe anemia -- a condition that can make you feel tired and weak. Beta thalassemia major also slows growth in infants and young children Fatigue. Abstract Beta-thalassemia minor (BTM) patients usually experience fatigue, bone pain complaint, and muscle weakness. Carnitine is an essential protein for transportation of long-chain fatty acids to the matrix for beta-oxidation. [ncbi.nlm.nih.gov] Here are some manifestations of fatigue
Beta thalassemia can cause damage to the liver and other organs, and pregnancy puts added strain on your liver. Your doctor will test how well your liver works before you get pregnant and will. BETA THALASSEMIA: In beta thalassemia, the heterozygous state (called thalassemia minor) is accompanied by no symptoms or at most by very mild anemia. The homozygous form of beta thalassemia (thalassemia major) is not immediately lethal because there is some production of Hb F, which does not contain beta chains. However, there is severe anemia with complications including progressive.
Beta Thalassemia affects your body at the genetic level. To understand more about Beta Thalassemia causes, it's important to learn about the role that genes play in how your body works Most children with moderate to severe thalassemia show signs and symptoms within their first two years of life. If your doctor suspects your child has thalassemia, he or she can confirm a diagnosis with blood tests. Blood tests can reveal the number of red blood cells and abnormalities in size, shape or color. Blood tests can also be used for DNA analysis to look for mutated genes Background: Beta-thalassemia minor (BTM) is a common benign condition that can be present in patients with diabetes mellitus. There are conflicting reports about the effect of BTM on glycated hemoglobin (gHb) measurements. We evaluated 6 gHb methods using samples from non-diabetic subjects with BTM
Other articles where Thalassemia minor is discussed: blood disease: Thalassemia and hemoglobinopathies: mild form of the disease, thalassemia minor, there is usually only slight or no anemia, and life expectancy is normal. Thalassemia major (Cooley anemia) is characterized by severe anemia, enlargement of the spleen, and body deformities associated with expansion of the bone marrow • A single deletion (α-thalassemia minor) - silent carrier state - RBC morphology and hemoglobin concentrations are usually normal • Beta thalassemia - Beta globin sequencing • The test examines the complete beta globin coding sequence, the splice sites and other intronic regions known to harbor mutations, the proximal promoter region, and the 5' and 3'UTR regions.
Abstract Beta-thalassemia minor (BTM) is a common benign condition that can be present in patients with diabetes mellitus. There are conflicting reports about the effect of BTM on glycated hemoglobin (gHb) measurements. We evaluated 6 gHb methods using samples from non-diabetic subjects with BTM. Samples submitted for hemoglobin phenotype analysis were evaluated. A total of 57 samples (30. Dec 1, 2015 - Thalassemia Minor - I have the trait and was often told to eat more iron - the exact opposite of what I needed. I even have reason to believe that my Tachycardia may be a result of taking iron pills. So I try and read up where I can and learn about this crazy trait I have! . See more ideas about iron pills, blood disorder, beta thalassemia Beta thalassemia minor (BTM) is a hereditary disease caused by defective globin synthesis and it is frequently asymptomatic or only mildly anemic. Female sexual dysfunction affects 21-41% of. Normally, beta thalassemia trait does not cause any health problems. Beta thalassemia trait is also known as beta thalassemia minor. If one parent has beta thalassemia trait and the other parent has normal hemoglobin A, there is a 50 percent (1 in 2) chance with each pregnancy of having a child with beta thalassemia trait. These are the. Diagnosed as an infant with beta thalassemia, a blood disorder, Zayed and his family were in search of treatment. That search ultimately led them to Dr. Kenn..
Beta-thalassemia disease is one of the most common congenital hemolytic anemia commonly found in the malarial belt areas including the Mediterranean, the Middle East, Transcaucasus, Africa, South and Southeast Asian countries, and China .It is inherited by autosomal recessive manner [1, 2].Beta-thalassemia disease is the result from the mutation of beta-globin genes causing decrease of beta. Clinically, beta-thalassemia is divided into thalassemia major which is transfusion dependent, thalassemia intermedia (of intermediate severity), and thalassemia minor that is asymptomatic. Acronym. B-THAL. Synonyms. Beta thalassemia Cooley's anemia Erythroblastic anemia Mediterranean anemia Thalassemia major Thalassemia minor. Keywords › Hereditary hemolytic anemia. Related websites. MIM i. HOW BETA (β)‑THALASSEMIA AFFECTS THE BODY. If β‑thalassemia β‑Thalassemia a genetic blood disorder that reduces or eliminates the production of β‑globin is not treated, or poorly treated, it can lead to: Anemia Anemia a condition where there aren't enough healthy red blood cells to carry adequate oxygen to the body's tissues (or lack of red blood cells Red Blood Cells a.
There are two main forms of BT: beta-thalassemia major (BTMa) and beta-thalassemia minor (BTMi). BTMa: When a person receives a mutated or damaged gene from both the parents, the condition is called BTMa. Here, both the beta-globin gene will be defective. BTMa causes moderate to severe symptoms and is also known as Cooley's anaemia. BTMi: When a person receives a single mutated or damaged gene. Beta-thalassemia has been clinically characterized into three forms, depending on disease severity: major, intermedia and minor. The most severe form is generally diagnosed shortly after birth and is characterized by life-threatening anemia. Pediatric patients do not grow and gain weight at the typical rates, and often have liver, heart and bone problems. Many patients with beta-thalassemia. Beta thalassemia intermedia. This type of thalassemia is common throughout the world. It results from the abnormal hemoglobin within the red blood cells. Because it is a less severe type, it is often found at a later age than beta thalassemia major. Transfusions are usually not needed. Thalassemia minor or thalassemia trait Beta thalassemia major (also called Cooley's anemia, after the discoverer) neither beta gene is not working properly; symptoms, which begin during the first year of life, include severe anemia; monthly blood transfusions needed; chelation therapy also is needed to remove excess iron that builds up in the body due to frequent blood transfusions ; Other types of thalassemia. Hemoglobin E beta.
. Klinische Symptomatik. Bei den β-Thalassämien können die β-Globinketten des Hämoglobins nicht oder nur unzureichend gebildet werden. Durch den kompensatorischen Einbau von γ- oder δ-Ketten ergeben sich abhängig vom Alter und der jeweiligen Form der β-Thalassämie in der Hb-Elektrophorese erhöhte Werte von HbF und HbA2. Je nach Schweregrad werden verschiedene Formen. Although β-thalassemia major represents the homozygous state, β-thalassemia minor represents the heterozygous state. Thalassemia minor results in a variable degree of the disease but, depending on the rate of β-chain production, usually presents as asymptomatic anemia of mild degree (the hemoglobin is 1-2 g/dL lower than normal persons of the same age and sex). There is no specific therapy for thalassemia minor during pregnancy, but if the anemia becomes more severe, transfusions are. Beta-thalassemia Minor; Patients with beta-thalassemia minor are typically asymptomatic and display a very mild hypochromic microcytic anemia that may be found incidentally. Occasionally, symptomology associated with a mild anemia may result. Beta-thalassemia Major; As a result of chronic ineffective erythropoiesis and extravascular hemolysis, patients with beta-thalassemia major may display a severe hypochromic microcytic anemia and be transfusion-dependent. The compensatory hyperplasia of. Beta thalassemia is an inherited blood disorder that reduces the production of hemoglobin, a protein in red blood cells that carries oxygen. If left untreated, beta thalassemia can be fatal. Normal adult hemoglobin is made of two proteins, alpha- and beta-globin
,819 © 2021 - The Calgary Guide to Understanding Disease Disclaime Millions of people worldwide suffer from Thalassemia. Alpha Thalassemia mainly occurs in families that have their roots in South East Asia, India, China or the Philippines. Beta Thalassemia occurs mainly in patients from areas around the Mediterranean Sea (Greece, Italy and the Middle East) or of Asian or African origin This rule will usually not apply in cases of beta thalassemia, particularly beta thalassemia minor where the RBCs are not normochromic and are microcytic, and where there is a disproportionate number of RBCs for the amount of hemoglobin that is present. The RDW reflects the variation in size of the RBCs Beta Thalassemia is a companion course to Alpha Thalassemia. This course defines and discusses the disorder beta thalassemia and its genetic mutations that not only differentiate it from alpha thalassemia, but dictate the severity of the disease. You will learn which laboratory tests are most useful for diagnosis
. At least 9 different genes direct the production of heme. Changes in these genes may lead to disorders of heme production, a group of conditions separate from the thalassemias. Alpha thalassemia occurs when a mutation in the gene that codes for alpha globin results in reduced or absent production of alpha globins. Beta thalassemia. The diagnosis of beta thalassemia minor usually is suggested by the presence of the following: Mild, isolated microcytic anemia Target cells on the peripheral blood smear (see the images below) A. Thalassemia minor usually presents as a mild, asymptomatic microcytic anemia and is detected through routine blood tests in adults and in older children. These laboratory findings should be.. Beta thalassemia is caused by a defect of the gene that controls hemoglobin production. There are three types: Beta thalassemia major (Cooley's anemia). This is the most severe type of beta thalassemia. It is often found during the first two years of life. Children often need frequent blood transfusions. This can cause serious problems with iron overload
Thalassemia Major and Thalassemia Minor Thalassaemia Major and Thalassaemia Minor Thalassaemia major is indicates anemia symptoms, enlarged liver and spleen. Thalassemia minor are asymptomatic which means, in addition to a very mild anemia Alpha-Thalassämie (α-Thalassämie) ist eine Form der Thalassämie, welche die Gene HBA1 und HBA2 mit einbezieht. Alpha-Thalassämie ist auf eine verminderte Produktion von 1,2,3 oder 4 alpha-Globin-Ketten zurückzuführen, was zu einem relativen hohem Überschuss an beta-Globin-Ketten führt. Der Grad der Störung hängt davon ab, welcher klinische Phänotyp vorhanden ist bzw. wie viele.
Beta thalassemia is a blood disorder. It affects the production of a protein in the red blood cells (RBCs). This protein, called hemoglobin, allows RBCs to carry oxygen to all parts of the body. Hemoglobin is made up of smaller parts, including alpha globin and beta globin These people are said to have 'beta-thalassemia minor' or 'beta-thalassemia trait.' In a small percentage of families, the condition is inherited in an autosomal dominant manner. In these cases, one mutated copy of the gene in each cell is enough to cause the signs and symptoms of beta-thalassemia
There are three general categories of beta thalassemia that also range from mild to severe in their effect on the body (Rund and Rachmilewitz, 1995). (1)Beta thalassemia Minor Also known as thalassemia Trait. In this condition, one of the two beta globin genes is abnormal but the lack of beta protein is not great enough to cause problems in th Thalassemia, classified as the main types α‐ and β‐thalassemia, is a single gene disorder resulting from globin chain synthesis impairment through the mutation or deletion of globin genes. The incidence of thalassemia is high worldwide, with high associated mortality. Therefore, treatment is important to improve patient outcomes Beta thalassemia major was first described by a Detroit pediatrician, Thomas Cooley, in 1925. The clinical picture he described is prevalent today in countries without the necessary resources to provide patients with chronic transfusions and desferoxamine therapy. Children who have untreated thalassemia major have ineffective erythropoiesis, decreased red cell deformability, and enhanced. In its major form, beta-thalassemia requires monthly transfusions and a treatment against the harmful effect of iron deposits caused by these transfusions. These only have a palliative effect. The curative treatment offered to these patients is generally an allogeneic transplant of bone marrow cells, when their clinical condition is not too fragile and one of their siblings is a compatible. They both have a beta thalassemia major phenotype. Hassan M. Yaish, MD University of Utah Salt Lake City, UT. The child needs beta gene molecular testing to determine if he is also a carrier for beta thalassemia, as well as for one alpha gene loss. We also need to see the red blood cell and mean corpuscular volume values, as well as iron testing. Geoffrey Wool, MD, PhD University of Chicago.
Beta-Thalassemia in 6 Major Markets 2017-2030: Total Prevalent Cases Highest in Italy, Followed by the United States and Germany Read full article September 1, 2020, 5:30 AM · 6 min rea Beta thalassemia major (Cooley's anemia). Both (two) beta chain genes have deletions, causing the most severe type of beta thalassemia. Thalassemia major patients need frequent blood transfusions and may not survive a normal lifespan. During the first 1 to 2 years of life, they can be pale, fussy, have a poor appetite, and have many infections. Without treatment, the spleen, liver, and heart. There are 2 major types of thalassemia - alpha thalassemia and beta thalassemia - named after defects that can occur in these protein chains. Alpha Thalassemia . Four genes, 2 from each parent, are required to make alpha globin protein chains. When 1 or more genes are missing, it produces alpha thalassemia. This chart describes the different types of alpha thalassemia. Missing alpha genes. See reference case on beta thalassemia major for details. Download Image . Views: 3216 . Downloads: 42 . Size: 0.05 MB. Related Images: #00060610 . Small red blood cells mimicking platelets #00060704 . Nodal extramedullary hematopoiesis and facial bone change in thalassemia #00061925 . Beta-thalassemia trait-Blood #00061926 . Beta-thalassemia trait-Blood. AMERICAN SOCIETY OF HEMATOLOGY. 2021 L. Patients with thalassemia intermedia have a moderate anemia and show a markedly heterogeneous hematologic picture, ranging in severity from that of the beta-thalassemia carrier state to that of thalassemia major. The characteristic hematologic features in carriers are microcytosis (reduced red blood cell volume), hypochromia (reduced red blood cell Hb content), increased HbA2 level (the minor.
Beta thalassemia minor or thalassemia trait. Only 1 gene is damaged. This causes less severe anemia. People with this type have a 1 in 2 chance of passing the gene to their children. If the other parent is not affected, their children will also have this form of the disorder. This type is further divided into: Thalassemia minima. There are few or no symptoms. Thalassemia intermedia. This. . It inhibits the production of hemoglobin and red blood cells. A person may have alpha or beta thalassemia, and symptoms depend on these types and how. Beta Thalassemia Minor. Local Business . Community See All. 322 people like this. 324 people follow this. About See All. Local Business. Page Transparency See More. Facebook is showing information to help you better understand the purpose of a Page. See actions taken by the people who manage and post content. Page created - August 31, 2016 . People. 322 likes. Related Pages. Thalassemia Minor.